Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
about
IMP dehydrogenase: structure, mechanism, and inhibition.Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania.The antibiotic potential of prokaryotic IMP dehydrogenase inhibitorsStructural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 geneEhMAPK, the mitogen-activated protein kinase from Entamoeba histolytica is associated with cell survivalAmplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania.A rapid, efficient and economical method for generating leishmanial gene targeting constructs.Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma brucei.IMP dehydrogenase from Pneumocystis carinii as a potential drug target.IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.Adaptive evolution of drug targets in producer and non-producer organisms.Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani.The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species.Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid.GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.The 63-kilobase circular amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection.
P2860
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P2860
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1991年の論文
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1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
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name
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@ast
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@en
type
label
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@ast
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@en
prefLabel
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@ast
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@en
P2093
P1476
Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani.
@en
P2093
P304
P407
P577
1991-01-01T00:00:00Z