Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. - Wikidata - awgldk - TriplyDB

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

http://www.wikidata.org/entity/Q33264071

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In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues.Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Powerful partners: Arabidopsis and chemical genomics African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts.Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.Arabidopsis plants deficient in plastidial glyceraldehyde-3-phosphate dehydrogenase show alterations in abscisic acid (ABA) signal transduction: interaction between ABA and primary metabolism Target identification for small bioactive molecules: finding the needle in the haystack.Development of a high-affinity inhibitor of the prostaglandin transporter Synthesis and systematic evaluation of dark resonance energy transfer (DRET)-based library and its application in cell imaging.Diversity-oriented approach for chemical biology.A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle.Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.Systematizing serendipity for cardiovascular drug discovery.ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes.From noncovalent to covalent bonds: a paradigm shift in target protein identification.Whole organism approaches to chemical genomics: the promising role of zebrafish (Danio rerio).Chemical genetics and its application to moonlighting in glycolytic enzymes.Affinity purification in target identification: the specificity challenge.5-Nitro-5'hydroxy-indirubin-3'oxime is a novel inducer of somatic cell transdifferentiation.GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death.Interactions between abscisic acid and plastidial glycolysis in Arabidopsis.The plastidial glyceraldehyde-3-phosphate dehydrogenase is critical for viable pollen development in Arabidopsis.Effect of dietary fat modification on subcutaneous white adipose tissue insulin sensitivity in patients with metabolic syndrome.Small-molecule mechanism of action studies in Caenorhabditis elegans.Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.Dark to light! A new strategy for large Stokes shift dyes: coupling of a dark donor with tunable high quantum yield acceptors

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P2860

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

http://www.wikidata.org/entity/Q33264071

description

2006 nî lūn-bûn

@nan

2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@ast

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@en

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@nl

type

label

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@ast

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@en

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@nl

prefLabel

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@ast

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

@en

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

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Nature Chemical Biology

P1476

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.

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P2093

Daniel P Walsh

http://www.w3.org/2001/XMLSchema#string

Fabio Piano

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Jaeki Min

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Ji-Young Lee

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John R Yates

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Kristin Gunsalus

http://www.w3.org/2001/XMLSchema#string

Mira Kang

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Patricia G Cipriani

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Sherry Niessen

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Sonya M Khersonsky

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P2860

Implication of a novel multiprotein Dam1p complex in outer kinetochore function

Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins

A PTEN-like phosphatase with a novel substrate specificity

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase.

Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening.

Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism.

Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG.

Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally derived NADH.

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55-59

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10.1038/NCHEMBIO833

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1

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3

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Young-Tae Chang

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2006-11-19T00:00:00Z

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6682943

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17115034

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