The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils.
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Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR ApproachAmyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host proteinAn Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril FormationTrinucleotide repeats: a structural perspectiveMutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.Ataxin-1 fusion partners alter polyQ lethality and aggregation.Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence.Orthogonal cross-seeding: an approach to explore protein aggregates in living cells.Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.The role of interruptions in polyQ in the pathology of SCA1.Location trumps length: polyglutamine-mediated changes in folding and aggregation of a host proteinPolyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophyThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseThe interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtinPolyglutamine neurodegeneration: protein misfolding revisited.In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence.Class A β-lactamases as versatile scaffolds to create hybrid enzymes: applications from basic research to medicine.Polyglutamine aggregates impair lipid membrane integrity and enhance lipid membrane rigidity.Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin.Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils.Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependentYeast prions form infectious amyloid inclusion bodies in bacteria.Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
P2860
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P2860
The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@ast
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@en
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@nl
type
label
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@ast
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@en
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@nl
prefLabel
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@ast
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@en
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@nl
P2093
P2860
P1433
P1476
The interplay between PolyQ an ...... g a reservoir of protofibrils.
@en
P2093
David J Thomas
Donatella Bulone
Laura Masino
P2860
P356
10.1371/JOURNAL.PONE.0000111
P407
P577
2006-12-27T00:00:00Z