Positive and negative design in stability and thermal adaptation of natural proteins
about
A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitansViral proteins acquired from a host converge to simplified domain architecturesProtein evolution along phylogenetic histories under structurally constrained substitution models.Amino acid composition of proteins reduces deleterious impact of mutations.Mining the entire Protein DataBank for frequent spatially cohesive amino acid patterns.The role of negative selection in protein evolution revealed through the energetics of the native state ensemble.Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models.A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutantsUse of machine learning algorithms to classify binary protein sequences as highly-designable or poorly-designableAnalysing the origin of long-range interactions in proteins using lattice models.Comparative metagenomic analysis of a microbial community residing at a depth of 4,000 meters at station ALOHA in the North Pacific subtropical gyreCalculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiaeTrade-off between positive and negative design of protein stability: from lattice models to real proteins.Tradeoff between stability and multispecificity in the design of promiscuous proteins.Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response.Reduction in structural disorder and functional complexity in the thermal adaptation of prokaryotes.De novo self-assembling collagen heterotrimers using explicit positive and negative design.Evolution of specificity in protein-protein interactionsTemperature adaptation at homologous sites in proteins from nine thermophile-mesophile species pairs.Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions.The fundamental tradeoff in genomes and proteomes of prokaryotes established by the genetic code, codon entropy, and physics of nucleic acids and proteinsStructural basis for the stability of a thermophilic methionine adenosyltransferase against guanidinium chloride.Protein thermostability prediction within homologous families using temperature-dependent statistical potentials.Stability curve prediction of homologous proteins using temperature-dependent statistical potentialsProtein misinteraction avoidance causes highly expressed proteins to evolve slowlyFolding without charges.Protein stability imposes limits on organism complexity and speed of molecular evolution.Amino-acid interactions in psychrophiles, mesophiles, thermophiles, and hyperthermophiles: insights from the quasi-chemical approximation.Low Temperature Adaptation Is Not the Opposite Process of High Temperature Adaptation in Terms of Changes in Amino Acid CompositionSubunit association as the stabilizing determinant for archaeal methionine adenosyltransferases.Mining bacterial genomes for novel arylesterase activityProteome Evolution of Deep-Sea Hydrothermal Vent Alvinellid Polychaetes Supports the Ancestry of Thermophily and Subsequent Adaptation to Cold in Some Lineages.Detecting selection on protein stability through statistical mechanical models of folding and evolutionMolecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins.Insights from molecular dynamics simulations for computational protein design.Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution.Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.Massively parallel sampling of lattice proteins reveals foundations of thermal adaptation.AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences.Is catalytic activity of chaperones a selectable trait for the emergence of heat shock response?
P2860
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P2860
Positive and negative design in stability and thermal adaptation of natural proteins
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Positive and negative design in stability and thermal adaptation of natural proteins
@ast
Positive and negative design in stability and thermal adaptation of natural proteins
@en
Positive and negative design in stability and thermal adaptation of natural proteins.
@nl
type
label
Positive and negative design in stability and thermal adaptation of natural proteins
@ast
Positive and negative design in stability and thermal adaptation of natural proteins
@en
Positive and negative design in stability and thermal adaptation of natural proteins.
@nl
prefLabel
Positive and negative design in stability and thermal adaptation of natural proteins
@ast
Positive and negative design in stability and thermal adaptation of natural proteins
@en
Positive and negative design in stability and thermal adaptation of natural proteins.
@nl
P2860
P1476
Positive and negative design in stability and thermal adaptation of natural proteins
@en
P2093
Igor N Berezovsky
Konstantin B Zeldovich
P2860
P356
10.1371/JOURNAL.PCBI.0030052
P577
2007-02-01T00:00:00Z
P5875
P698
P818
q-bio/0607003