Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
about
Polo-like kinase 4: the odd one out of the familyPolo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplicationThe SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplicationCalcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsPLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cyclePolo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoPlk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cellsThe 3Ms of central spindle assembly: microtubules, motors and MAPsPLK-1 Targeted Inhibitors and Their Potential against TumorigenesisPolo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentSelective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brainProteotoxic stress increases nuclear localization of ataxin-3RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplatePolo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.PLK1 down-regulates parainfluenza virus 5 gene expressionPhosphorylation of synucleins by members of the Polo-like kinase family.Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screenThe transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells.Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage.Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylationIdentification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma bruceiRecent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyPolo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.Polo-like kinase 1 inhibitors in mono- and combination therapies: a new strategy for treating malignancies.KinView: a visual comparative sequence analysis tool for integrated kinome research.PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis.Binding of STIL to Plk4 activates kinase activity to promote centriole assemblyPolo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.Inhibition of polo-like kinase 1 induces cell cycle arrest and sensitizes glioblastoma cells to ionizing radiation.Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001.
P2860
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P2860
Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Pharmacological and functional ...... tor and substrate specificity.
@ast
Pharmacological and functional ...... tor and substrate specificity.
@en
Pharmacological and functional ...... tor and substrate specificity.
@nl
type
label
Pharmacological and functional ...... tor and substrate specificity.
@ast
Pharmacological and functional ...... tor and substrate specificity.
@en
Pharmacological and functional ...... tor and substrate specificity.
@nl
prefLabel
Pharmacological and functional ...... tor and substrate specificity.
@ast
Pharmacological and functional ...... tor and substrate specificity.
@en
Pharmacological and functional ...... tor and substrate specificity.
@nl
P2093
P356
P1433
P1476
Pharmacological and functional ...... tor and substrate specificity.
@en
P2093
Eric F Johnson
Keith W Woods
Vincent L Giranda
P304
P356
10.1021/BI7008745
P407
P577
2007-07-27T00:00:00Z