Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences.
about
Targeting DNA double-strand breaks with TAL effector nucleasesEfficient targeting of a SCID gene by an engineered single-chain homing endonucleaseCrystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineeringGeneration of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteinsSpecificity in computational protein designOptimization algorithms for functional deimmunization of therapeutic proteins.Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.DNA nicks promote efficient and safe targeted gene correction.Computational design of affinity and specificity at protein-protein interfacesMeganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.Increasing cloning possibilities using artificial zinc finger nucleasesCrystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7.Targeted approaches for gene therapy and the emergence of engineered meganucleases.Reprogramming homing endonuclease specificity through computational design and directed evolution.Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign.Generation of novel nucleases with extended specificity by rational and combinatorial strategies.Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.Molecular scissors for in situ cellular repair.Genome modifications in plant cells by custom-made restriction enzymes.Recent advances in targeted genome engineering in mammalian systems.Computational design gains momentum in enzyme catalysis engineering.Rational engineering of type II restriction endonuclease DNA binding and cleavage specificity.Identification of conserved features of LAGLIDADG homing endonucleases.Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function
P2860
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P2860
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Computer design of obligate he ...... tting of custom DNA sequences.
@ast
Computer design of obligate he ...... tting of custom DNA sequences.
@en
Computer design of obligate he ...... tting of custom DNA sequences.
@nl
type
label
Computer design of obligate he ...... tting of custom DNA sequences.
@ast
Computer design of obligate he ...... tting of custom DNA sequences.
@en
Computer design of obligate he ...... tting of custom DNA sequences.
@nl
prefLabel
Computer design of obligate he ...... tting of custom DNA sequences.
@ast
Computer design of obligate he ...... tting of custom DNA sequences.
@en
Computer design of obligate he ...... tting of custom DNA sequences.
@nl
P2093
P2860
P356
P1476
Computer design of obligate he ...... tting of custom DNA sequences.
@en
P2093
François Stricher
Frédéric Pâques
Luis Serrano
P2860
P304
P356
10.1093/NAR/GKN059
P407
P577
2008-02-14T00:00:00Z