Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
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The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria VaccineDifferential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSAThe Structure of a Chondroitin Sulfate-binding Domain Important in Placental MalariaThe Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved StructureStructural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during PregnancyAntigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malariaIdentification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSADifferential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area.Functional antibodies against VAR2CSA in nonpregnant populations from colombia exposed to Plasmodium falciparum and Plasmodium vivax.Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies.Mapping epitopes of the Plasmodium vivax Duffy binding protein with naturally acquired inhibitory antibodies.Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer.Insight into antigenic diversity of VAR2CSA-DBL5ε domain from multiple Plasmodium falciparum placental isolatesAntibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolatesEvaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal.Advances and challenges in malaria vaccine development.Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSADesigning a VAR2CSA-based vaccine to prevent placental malaria.Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α.Bacterial superglue enables easy development of efficient virus-like particle based vaccines.Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placentaThe antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding siteIdentification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high Plasmodium falciparum transmission.Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assayChondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.Structural interactions in chondroitin 4-sulfate mediated adherence of Plasmodium falciparum infected erythrocytes in human placenta during pregnancy-associated malaria.Structural insights into chondroitin sulphate A binding Duffy-binding-like domains from Plasmodium falciparum: implications for intervention strategies against placental malaria.Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris.Malaria evolution in South Asia: knowledge for control and elimination.Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes.Pre-clinical and clinical development of the first placental malaria vaccine.The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria.
P2860
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P2860
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@ast
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@en
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.
@nl
type
label
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@ast
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@en
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.
@nl
prefLabel
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@ast
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@en
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.
@nl
P2093
P2860
P50
P1433
P1476
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
@en
P2093
Madeleine Dahlbäck
Mafalda Resende
Pernille Andersen
Thomas S Rask
Thor Theander
P2860
P356
10.1371/JOURNAL.PPAT.0040042
P577
2008-02-01T00:00:00Z