Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy
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Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSAStructure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibitionDimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARCInsights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparumStructural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine designIgM, Fc mu Rs, and malarial immune evasionTowards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6epsilon domain of VAR2CSA.Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies.Insight into antigenic diversity of VAR2CSA-DBL5ε domain from multiple Plasmodium falciparum placental isolatesImmunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolatesSubdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domainsInsect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytesCytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced.VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placentaElucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.Using the PfEMP1 head structure binding motif to deal a blow at severe malaria.How specific is Plasmodium falciparum adherence to chondroitin 4-sulfate?Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental malaria.Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactionsMultilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria.Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.Malaria adhesins: structure and function.Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein familiesPre-clinical and clinical development of the first placental malaria vaccine.Optimization of protein-protein docking for predicting Fc-protein interactions.Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.
P2860
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P2860
Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@ast
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@en
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@nl
type
label
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@ast
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@en
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@nl
prefLabel
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@ast
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@en
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@nl
P2093
P2860
P1476
Structural Comparison of Two C ...... nt in Malaria during Pregnancy
@en
P2093
Duncan R Bull
Judith M D Philip
Matthew K Higgins
Pongsak Khunrae
P2860
P304
P356
10.1016/J.JMB.2009.08.027
P407
P577
2009-10-16T00:00:00Z