Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle.
about
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathwayAtrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cellsThe unstable repeats--three evolving faces of neurological diseasedAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophyPolyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicityFunctional characterization of rare FOXP2 variants in neurodevelopmental disorder.Probing protein aggregation using discrete molecular dynamicsInactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.Polymorphism at the Clock gene predicts phenology of long-distance migration in birds.A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosisOligonucleotide-based strategies to combat polyglutamine diseases.An out-of-frame overlapping reading frame in the ataxin-1 coding sequence encodes a novel ataxin-1 interacting proteinCorrelation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC contentPreclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityA common gene expression signature in Huntington's disease patient brain regions.Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Proceedings of the fourth international conference on central hypoventilation.Autophagy and cell death in model organisms.A yeast model for polyalanine-expansion aggregation and toxicityChanges in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.Fragment based G-QSAR and molecular dynamics based mechanistic simulations into hydroxamic-based HDAC inhibitors against spinocerebellar ataxia.Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2)The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.Molecular dynamics analysis of the aggregation propensity of polyglutamine segmentsDysregulation of core components of SCF complex in poly-glutamine disordersPPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.Epigenetics in nucleotide repeat expansion disorders.Atrophin proteins: an overview of a new class of nuclear receptor corepressorsHuntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
P2860
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P2860
Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle.
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@ast
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@en
type
label
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@ast
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@en
prefLabel
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@ast
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@en
P356
P1433
P1476
Polyglutamine neurodegenerativ ...... iption: assembling the puzzle.
@en
P2093
Brigit E Riley
P304
P356
10.1101/GAD.1436506
P50
P577
2006-08-01T00:00:00Z