Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.
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Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolutionA homeodomain protein binds to gamma-globin gene regulatory sequencesA novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expressionA homeodomain protein related to caudal regulates intestine-specific gene transcriptionDNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobinZinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for bindingT to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic miceNovel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene.Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genesAnalysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease.Identification and characterization of mechanistically distinct inducers of gamma-globin transcriptionEditing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells.High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster.Hereditary overexpression of adenosine deaminase in erythrocytes: evidence for a cis-acting mutation.The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement proteinProtein-DNA interactions upstream from the human A gamma globin geneStructure and function of the enhancer 3' to the human A gamma globin geneSaturation mutagenesis of the UASNTR (GATAA) responsible for nitrogen catabolite repression-sensitive transcriptional activation of the allantoin pathway genes in Saccharomyces cerevisiae.Phylogenetic footprinting reveals unexpected complexity in trans factor binding upstream from the epsilon-globin gene.Understanding mechanisms of gamma-globin gene regulation to develop strategies for pharmacological fetal hemoglobin induction.Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties.Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoterRoles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.Purification and characterization of an erythroid cell-specific factor that binds the murine alpha- and beta-globin genes.Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.Regulated expression of human alpha- and beta-globin genes in transient heterokaryonsGATA factors in gastrointestinal malignancy.Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene.Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein.Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression.Globin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.Role of NF-Y in in vivo regulation of the gamma-globin geneIntronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene.Increased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Analysis of the mechanism of action of the Brazilian type (Agamma-195 C --> G) of hereditary persistence of fetal hemoglobin.
P2860
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P2860
Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.
description
1988 nî lūn-bûn
@nan
1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@ast
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@en
type
label
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@ast
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@en
prefLabel
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@ast
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@en
P2093
P2860
P356
P1476
Nuclear proteins that bind the ...... rsistence of fetal hemoglobin.
@en
P2093
C I Sartor
D L Gumucio
F S Collins
M F Riordan
P2860
P304
P356
10.1128/MCB.8.12.5310
P407
P577
1988-12-01T00:00:00Z