Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. - Wikidata - awgldk - TriplyDB

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

http://www.wikidata.org/entity/Q33373235

about

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells PKD signaling and pancreatitis Protein kinase D enzymes: novel kinase targets in pancreatic cancer Inhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR Signaling A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network A targeted library screen reveals a new inhibitor scaffold for protein kinase D SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Design, Synthesis, and Biological Evaluation of PKD Inhibitors.A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites.GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.Protein kinase d as a potential chemotherapeutic target for colorectal cancer.CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.Protein kinase D as a potential new target for cancer therapy.Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors.Role of protein kinase D signaling in pancreatic cancer Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2 Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway.Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice Genkwadaphnin induces IFN-γ via PKD1/NF-κB/STAT1 dependent pathway in NK-92 cells.Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle

P2860

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P2860

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

http://www.wikidata.org/entity/Q33373235

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@ast

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@en

type

label

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@ast

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@en

prefLabel

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@ast

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@en

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Potent and selective disruptio ...... ity by a benzoxoloazepinolone.

@en

P2093

Courtney R LaValle

http://www.w3.org/2001/XMLSchema#string

Jun Chen

http://www.w3.org/2001/XMLSchema#string

Karla Bravo-Altamirano

http://www.w3.org/2001/XMLSchema#string

Q Jane Wang

http://www.w3.org/2001/XMLSchema#string

Rebecca Barrett

http://www.w3.org/2001/XMLSchema#string

P2860

PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu

Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases

Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network

E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer

The protein kinase complement of the human genome

PKCu is a novel, atypical member of the protein kinase C family

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.

Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5

Gbetagamma-mediated regulation of Golgi organization is through the direct activation of protein kinase D

P304

33516-33526

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scholarly article

P356

10.1074/JBC.M805358200

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P407

P433

48

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P478

283

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P50

Karthik V. Giridhar

Elizabeth R Sharlow

Stephanie Leimgruber

P577

2008-09-30T00:00:00Z

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P698

18829454

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P932

2586241

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