Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. - Wikidata - awgldk - TriplyDB

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

http://www.wikidata.org/entity/Q33376049

about

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.The contribution of mouse models to the understanding of constitutional thrombocytopenia Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function Non-muscle myosin II takes centre stage in cell adhesion and migration Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability.Clinical manifestation and molecular genetic characterization of MYH9 disorders.Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias.Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.The role of calpain-myosin 9-Rab7b pathway in mediating the expression of Toll-like receptor 4 in platelets: a novel mechanism involved in α-granules trafficking.Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.Molecular basis of inherited thrombocytopenias.Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway.The role of vertebrate nonmuscle Myosin II in development and human disease.Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1)Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood Platelet retraction force measurements using flexible post force sensors.Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.Mouse models of diseases of megakaryocyte and platelet homeostasis.Regulating thrombus growth and stability to achieve an optimal response to injury.Advances in our understanding of the molecular basis of disorders of platelet function.The myosin family: unconventional roles of actin-dependent molecular motors in immune cells.Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control.The effects of arterial flow on platelet activation, thrombus growth, and stabilization.New explanations for old observations: marginal band coiling during platelet activation.Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress.What Is the Biological and Clinical Relevance of Fibrin?New Concepts and Mechanisms of Platelet Activation Signaling.Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.Role of tumor suppressor p53 in megakaryopoiesis and platelet function.

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P2860

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

http://www.wikidata.org/entity/Q33376049

description

2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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type

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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Megakaryocyte-restricted MYH9 ...... let aggregation and secretion.

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Megakaryocyte-restricted MYH9 ...... elet aggregation and secretion

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Boris Aleil

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Catherine Ravanat

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Christian Gachet

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