Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

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http://www.wikidata.org/entity/Q33391846
The complotype: dictating risk for inflammation and infectionStructural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.Cryo-EM and the elucidation of new macromolecular structures: Random Conical Tilt revisited.Factor H binds to the hypervariable region of many Streptococcus pyogenes M proteins but does not promote phagocytosis resistance or acute virulence.Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease riskUnique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopyRare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activityMutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins.The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient miceManipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.Progress and Trends in Complement TherapeuticsA novel mutation in the complement component 3 gene in a patient with selective IgA deficiency.Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulationInsights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase.Structural insights on complement activation.Targeting complement-mediated immunoregulation for cancer immunotherapy.
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Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

Item
http://www.wikidata.org/entity/Q33391846
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2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Lessons from functional and st ...... omplement alternative pathway.
@ast
Lessons from functional and st ...... omplement alternative pathway.
@en
type
label
Lessons from functional and st ...... omplement alternative pathway.
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Lessons from functional and st ...... omplement alternative pathway.
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prefLabel
Lessons from functional and st ...... omplement alternative pathway.
@ast
Lessons from functional and st ...... omplement alternative pathway.
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P1476
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P1433
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Lessons from functional and st ...... complement alternative pathway
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P2093
P304
P31
P356
10.1016/J.BBADIS.2010.09.002
P407
P433
P478
P50
P577
P5875
P698