Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
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Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting ProteinDiscovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking ApproachDiscovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based designBcL-xL conformational changes upon fragment binding revealed by NMRSelectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuationsNMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexesA competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalNavitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapyStructure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regressionDARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.Recent applications of isotopic labeling for protein NMR in drug discovery.Many players in BCL-2 family affairs.Oncogenic protein interfaces: small molecules, big challenges.Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia.Silver-catalyzed allenylation and enantioselective propargylation reactions of ketones.Discovery of Inhibitors of Protein-Protein Interactions Using Fragment-Based Methods
P2860
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P2860
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@ast
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@en
type
label
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@ast
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@en
prefLabel
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@ast
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@en
P2093
P1476
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
@en
P2093
Andrew M Petros
Chaohong Sun
Cheol-Min Park
Emily Gramling
Haichao Zhang
Jamey Mack
Jeffrey R Huth
Karl Walter
Paul Nimmer
P304
P356
10.1016/J.BMCL.2010.09.033
P407
P577
2010-09-15T00:00:00Z