Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. - Wikidata - awgldk - TriplyDB

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

http://www.wikidata.org/entity/Q33459240

about

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1 The role of oxidative stress in Parkinson's disease Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1 Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons.A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.Parkinson's disease: insights from pathways.A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.Oxidative stress causes reversible changes in mitochondrial permeability and structure.Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity Unravelling the role of defective genes.Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease.Autophagy-mediated turnover of dynamin-related protein 1.Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.Loss of PINK1 impairs stress-induced autophagy and cell survival Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease.

P2860

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P2860

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

http://www.wikidata.org/entity/Q33459240

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2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Mitochondrial alterations in P ...... of dynamin-related protein 1.

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Mitochondrial alterations in P ...... of dynamin-related protein 1.

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Mitochondrial alterations in P ...... of dynamin-related protein 1.

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Mitochondrial alterations in P ...... of dynamin-related protein 1.

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Alexandra Beilina

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Anna Sandebring

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David W Miller

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Homira Behbahani

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Ibardo Zambrano

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Kelly Jean Thomas

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Marcel van der Brug

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Richard F Cowburn

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Rili Ahmad

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P2860

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

The kinase domain of mitochondrial PINK1 faces the cytoplasm

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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Megan M. Cleland

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