Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.
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How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeThe apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes)The emergence of human-evolutionary medical genomicsNicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from PellagraTrade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death.Aging genetics and aging.Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in miceApolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity.Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious loadGenomics of human health and agingArabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitroAge, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.Functional primate genomics--leveraging the medical potential.Long-standing balancing selection in the THBS4 gene: influence on sex-specific brain expression and gray matter volumes in Alzheimer disease.APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.
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P2860
Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Selection on alleles affecting ...... e example of apolipoprotein E.
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Selection on alleles affecting ...... e example of apolipoprotein E.
@en
Selection on alleles affecting ...... e example of apolipoprotein E.
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type
label
Selection on alleles affecting ...... e example of apolipoprotein E.
@ast
Selection on alleles affecting ...... e example of apolipoprotein E.
@en
Selection on alleles affecting ...... e example of apolipoprotein E.
@nl
prefLabel
Selection on alleles affecting ...... e example of apolipoprotein E.
@ast
Selection on alleles affecting ...... e example of apolipoprotein E.
@en
Selection on alleles affecting ...... e example of apolipoprotein E.
@nl
P2860
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P1476
Selection on alleles affecting ...... he example of apolipoprotein E
@en
P2860
P304
P356
10.1371/JOURNAL.PONE.0010022
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P577
2010-04-02T00:00:00Z