Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
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Novel phenotypes of prediabetes?Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetesCommon variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clampLong noncoding RNA variations in cardiometabolic diseases.Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.β-Cell failure in type 2 diabetes.Predicting diabetic nephropathy using a multifactorial genetic model.Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humansUse of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes.Joint analysis of multiple biomarkers for identifying type 2 diabetes in middle-aged and older Chinese: a cross-sectional studyRp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 MiceHyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects.SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.Functional annotation of sixty-five type-2 diabetes risk SNPs and its application in risk predictionGenetic variants in MTNR1B affecting insulin secretion.Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling.Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia.A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.CDKN2A/B T2D GWAS Risk-SNPs Impact Locus Gene Expression and Proliferation in Human Islets.The CDKAL1 gene is associated with impaired insulin secretion and glucose-related traits: the Cardiometabolic Risk in Chinese (CRC) study.High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.
P2860
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P2860
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Combined risk allele score of ...... n during hyperglycemic clamps.
@ast
Combined risk allele score of ...... n during hyperglycemic clamps.
@en
Combined risk allele score of ...... n during hyperglycemic clamps.
@nl
type
label
Combined risk allele score of ...... n during hyperglycemic clamps.
@ast
Combined risk allele score of ...... n during hyperglycemic clamps.
@en
Combined risk allele score of ...... n during hyperglycemic clamps.
@nl
prefLabel
Combined risk allele score of ...... n during hyperglycemic clamps.
@ast
Combined risk allele score of ...... n during hyperglycemic clamps.
@en
Combined risk allele score of ...... n during hyperglycemic clamps.
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
Combined risk allele score of ...... n during hyperglycemic clamps.
@en
P2093
Andreas Fritsche
Annemarie M Simonis-Bik
Elisabeth M Eekhoff
Els C van Hove
Erwin Reiling
Fausto Machicao
J Antonie Maassen
Kerstin Kirchhoff
Mark H H Kramer
Marlous J Groenewoud
P2860
P304
P356
10.2337/DB09-0736
P407
P50
P577
2009-10-06T00:00:00Z