about
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE studyCommon variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clampCombined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus.Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study.Mitochondrial diabetes and its lessons for common Type 2 diabetes.Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.Mitochondrial diabetes: molecular mechanisms and clinical presentation.A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.Molecular mechanisms of mitochondrial diabetes (MIDD).New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands.A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies.A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype.BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies.Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus.Genetic factors and insulin secretion: gene variants in the IGF genes.Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control.Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp.Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.Tumor necrosis factor-alpha plays an important role in restenosis development.Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men.HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.
P50
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P50
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hulumtues
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Leen M 't Hart
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Leen M 't Hart
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Leen M 't Hart
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P106
P21
P31
P496
0000-0003-4401-2938