Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice
about
The epigenetic landscape of acute myeloid leukemiaRapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strengthASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repressionThe ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expressionASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemiaAdditional sex combs-like family genes are required for normal cardiovascular developmentMyelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutationsDeletion of Asxl1 results in myelodysplasia and severe developmental defects in vivoThe distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse modelThe HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modificationsDe novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndromeAdditional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targetsThe molecular basis of myeloid malignancies.Drosophila Cyclin G and epigenetic maintenance of gene expression during developmentEpigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.Molecular pathophysiology of myelodysplastic syndromes.De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.Functional and cancer genomics of ASXL family membersLoss of Asxl1 leads to myelodysplastic syndrome-like disease in miceTranscriptional and epigenetic networks in haematological malignancy.Molecular biology of myelodysplastic syndromes.Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms.Chromatin modifiers and the promise of epigenetic therapy in acute leukemiaMolecular genetics of myelofibrosis and its associated disease phenotypes.Recurring mutations in myeloproliferative neoplasms alter epigenetic regulation of gene expressionPrognosis of Primary Myelofibrosis in the Genomic EraThe Role of Additional Sex Combs-Like Proteins in Cancer.Primary myelofibrosis: current therapeutic options.ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.Clinical management of patients with ASXL1 mutations and Bohring-Opitz syndrome, emphasizing the need for Wilms tumor surveillance.Two novel patients with Bohring-Opitz syndrome caused by de novo ASXL1 mutations.ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylationAsxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis
P2860
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P2860
Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@ast
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@en
type
label
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@ast
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@en
prefLabel
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@ast
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@en
P2093
P2860
P1476
Additional sex combs-like 1 be ...... ly interacts with Cbx2 in mice
@en
P2093
C D Helgason
J Chevalier
R K Humphries
P2860
P356
10.1016/J.YDBIO.2009.10.004
P407
P577
2009-10-13T00:00:00Z