Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.
about
Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response elementKu recruits the XRCC4-ligase IV complex to DNA endsXRCC4's interaction with XLF is required for coding (but not signal) end joiningAutophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsRAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Ku86 is essential in human somatic cells.The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinaseActivation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination.V(D)J recombination: links to transposition and double-strand break repair.What prevents intermolecular V(D)J recombination?Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.Sensing of intermediates in V(D)J recombination by ATM.Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationThe catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombinationV(D)J recombination: how to tame a transposase.The life and death of DNA-PK.DNA-dependent protein kinase activity is not required for immunoglobulin class switching.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.DNA-dependent protein kinase and its inhibition in support of radiotherapy.The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.Paradigm switching in the germinal center.
P2860
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P2860
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Analysis of variable (diversit ...... al and coding joint formation.
@ast
Analysis of variable (diversit ...... al and coding joint formation.
@en
type
label
Analysis of variable (diversit ...... al and coding joint formation.
@ast
Analysis of variable (diversit ...... al and coding joint formation.
@en
prefLabel
Analysis of variable (diversit ...... al and coding joint formation.
@ast
Analysis of variable (diversit ...... al and coding joint formation.
@en
P2093
P2860
P356
P1476
Analysis of variable (diversit ...... al and coding joint formation.
@en
P2093
P2860
P304
15559-15564
P356
10.1073/PNAS.95.26.15559
P407
P577
1998-12-01T00:00:00Z