The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.
about
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinaseColocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic controlRole that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysisA GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-cateninDeficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistanceFlexible nets. The roles of intrinsic disorder in protein interaction networks.Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).Pathogenesis of insulin resistance in skeletal muscle.Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.Kinase-Catalyzed Biotinylation.Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster.The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster.Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?A simple matter of life and death-the trials of postnatal Beta-cell mass regulationSingle-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPITGSK-3 is a viable potential target for therapeutic intervention in bipolar disorder.Heart in diabetes: not only a macrovascular disease.Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy.Functional analysis of proteins and protein species using shotgun proteomics and linear mathematics.Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.Myocardial glycogen dynamics: new perspectives on disease mechanisms.Phosphorylation of glycogen synthase kinase-3β in metabolically abnormal obesity affects immune stimulation-induced cytokine production.Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).Regulation of hepatic glucose metabolism in health and disease.Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq.Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor.Deconstructing GSK-3: The Fine Regulation of Its Activity.Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle.Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes.A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition.Biological targets for isatin and its analogues: Implications for therapy.Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of beta-catenin and elicits distinct features of cardiomyocyte hypertrophy.Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.
P2860
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P2860
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@ast
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@en
type
label
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@ast
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@en
prefLabel
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@ast
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@en
P2860
P356
P1476
The Croonian Lecture 1998. Ide ...... n insulin signal transduction.
@en
P2093
P2860
P304
P356
10.1098/RSTB.1999.0399
P407
P577
1999-02-01T00:00:00Z