The SCL gene: from case report to critical hematopoietic regulator.
about
Fast and sensitive multiple alignment of large genomic sequencesPotentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoproteinA critical role for the transcription factor Scl in platelet production during stress thrombopoiesisDifferential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineagesETO2 coordinates cellular proliferation and differentiation during erythropoiesisMicroRNA fingerprints during human megakaryocytopoiesisA pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblastsTranscriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL lociGradient of E2A activity in B-cell development.The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells.Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats.Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development.Creating cellular diversity through transcription factor competitionCauses of oncogenic chromosomal translocation.Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis.Regulation of the stem cell leukemia (SCL) gene: a tale of two fishesThe scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.The biochemistry of hematopoietic stem cell development.Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.SCL assembles a multifactorial complex that determines glycophorin A expression.Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts.Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell RNA-sequencing.The Role of TAL1 in Hematopoiesis and Leukemogenesis.
P2860
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P2860
The SCL gene: from case report to critical hematopoietic regulator.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The SCL gene: from case report to critical hematopoietic regulator.
@ast
The SCL gene: from case report to critical hematopoietic regulator.
@en
type
label
The SCL gene: from case report to critical hematopoietic regulator.
@ast
The SCL gene: from case report to critical hematopoietic regulator.
@en
prefLabel
The SCL gene: from case report to critical hematopoietic regulator.
@ast
The SCL gene: from case report to critical hematopoietic regulator.
@en
P1433
P1476
The SCL gene: from case report to critical hematopoietic regulator
@en
P2093
P304
P407
P577
1999-05-01T00:00:00Z