Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism
about
Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slicesZinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.Zinc enhances ethanol modulation of the alpha1 glycine receptor.Molecular targets and mechanisms for ethanol action in glycine receptorsGlycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofolCharge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptorsPhysiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.Selection for drinking in the dark alters brain gene coexpression networks.Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.The Glycine Receptor-A Functionally Important Primary Brain Target of Ethanol.
P2860
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P2860
Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism
description
2004 nî lūn-bûn
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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@ast
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@en
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@nl
type
label
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@ast
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@en
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@nl
prefLabel
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@ast
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@en
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@nl
P2093
P1476
Multiple sites of ethanol acti ...... itivity to pressure antagonism
@en
P2093
Daniel K Crawford
James R Trudell
Ronald L Alkana
S John Mihic
P304
P356
10.1111/J.1471-4159.2004.02390.X
P407
P577
2004-06-01T00:00:00Z