Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases - Wikidata - awgldk - TriplyDB

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

http://www.wikidata.org/entity/Q33613123

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases Redox control of protein degradation Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose The neurology of mTOR Cutting through the complexities of mTOR for the treatment of stroke Genetically engineered mouse models of Parkinson's disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Targeting disease through novel pathways of apoptosis and autophagy Autophagy and neurodegeneration Autophagy modulation as a potential therapeutic target for diverse diseases Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Therapeutic targeting of autophagy in neurodegenerative and infectious diseases The role of autophagy in Parkinson's disease Autophagy modulation as a target for anticancer drug discovery Protein degradation pathways in Parkinson's disease: curse or blessing Sorting through the roles of beclin 1 in microglia and neurodegeneration Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease It's a cell-eat-cell world: autophagy and phagocytosis.Therapeutic Targeting of Autophagy Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease Regulation of autophagy by Beclin 1 in the heart Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity Autophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesis Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease Processing of optineurin in neuronal cells Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease Spermidine protects against α-synuclein neurotoxicity.The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers.Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

http://www.wikidata.org/entity/Q33613123

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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type

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

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JNEUROSCI.4390-09.2009

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Journal of Neuroscience

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Beclin 1 gene transfer activat ...... inson's and Lewy body diseases

@en

P2093

Anthony Adame

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Brian Spencer

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Christina Patrick

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Margarita Trejo

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Rewati Potkar

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Ryan Gindi

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Tony Wyss-Coray

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P2860

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

Ambra1 regulates autophagy and development of the nervous system

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease

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13578-13588

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10.1523/JNEUROSCI.4390-09.2009

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43

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29

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Eliezer Masliah

Edward Rockenstein

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38043644

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19864570

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Parkinson's disease

neurodegeneration

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2812014

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