Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
about
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseMolecular determinants of α-synuclein mutants' oligomerization and membrane interactionsMCL-1 is a stress sensor that regulates autophagy in a developmentally regulated mannerReduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's diseaseDisrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brainNew Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of AutophagyUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesRedox control of protein degradationDeconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeThe neurology of mTORCutting through the complexities of mTOR for the treatment of strokeGenetically engineered mouse models of Parkinson's diseasePathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseTargeting disease through novel pathways of apoptosis and autophagyAutophagy and neurodegenerationAutophagy modulation as a potential therapeutic target for diverse diseasesShedding new light on neurodegenerative diseases through the mammalian target of rapamycinTherapeutic targeting of autophagy in neurodegenerative and infectious diseasesThe role of autophagy in Parkinson's diseaseAutophagy modulation as a target for anticancer drug discoveryProtein degradation pathways in Parkinson's disease: curse or blessingSorting through the roles of beclin 1 in microglia and neurodegenerationBeclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complexSpreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegansPeripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's diseaseIt's a cell-eat-cell world: autophagy and phagocytosis.Therapeutic Targeting of AutophagyAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseRegulation of autophagy by Beclin 1 in the heartParkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synucleinAutophagy in Neurodegenerative Diseases and Metal NeurotoxicityAutophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesisGenetic and chemical activation of TFEB mediates clearance of aggregated α-synucleinOverexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph diseaseProcessing of optineurin in neuronal cellsPassive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body diseaseSpermidine protects against α-synuclein neurotoxicity.The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers.Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.
P2860
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P2860
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@ast
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@en
type
label
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@ast
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@en
prefLabel
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@ast
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@en
P2093
P2860
P921
P1476
Beclin 1 gene transfer activat ...... inson's and Lewy body diseases
@en
P2093
Anthony Adame
Brian Spencer
Christina Patrick
Margarita Trejo
Rewati Potkar
Ryan Gindi
Tony Wyss-Coray
P2860
P304
13578-13588
P356
10.1523/JNEUROSCI.4390-09.2009
P407
P577
2009-10-01T00:00:00Z