Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.
about
K11-linked ubiquitin chains as novel regulators of cell divisionAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationReduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutationTargeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.Trial Watch: Proteasomal inhibitors for anticancer therapyReprogramming to pluripotency can conceal somatic cell chromosomal instabilityUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisOverexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaOsteosarcomagenesis: modeling cancer initiation in the mouse.Microtubule-dependent regulation of mitotic protein degradation.Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome.Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesionsRIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytesCdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.Histone modifications and chromatin organization in prostate cancerHigh expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression.Development of inhibitors in the ubiquitination cascade.Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationPhospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.Cyclin B2 and p53 control proper timing of centrosome separationKnockdown of UbcH10 enhances the chemosensitivity of dual drug resistant breast cancer cells to epirubicin and docetaxel.Androgen receptor-driven chromatin looping in prostate cancer.Epigenetics in prostate cancer.Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.Immunohistochemical analysis of the ubiquitin-conjugating enzyme UbcH10 in lung cancer: a useful tool for diagnosis and therapy.The APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisA monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2Independent and functional validation of a multi-tumour-type proliferation signature.Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Gene expression in sheep carotid arteries: major changes with maturational development.Aneuploidy in health, disease, and aging.State of the APC/C: organization, function, and structure.UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancerNew insights into the troubles of aneuploidy
P2860
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P2860
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@ast
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@en
type
label
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@ast
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@en
prefLabel
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@ast
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@en
P2093
P2860
P356
P1476
Overexpression of the E2 ubiqu ...... gregation and tumor formation.
@en
P2093
Jan M van Deursen
Janine H van Ree
Karthik B Jeganathan
Liviu Malureanu
P2860
P304
P356
10.1083/JCB.200906147
P407
P577
2010-01-01T00:00:00Z