Mapping pathological phenotypes in a mouse model of CDKL5 disorder
about
Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to FunctionPathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studiesA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to noveltyMolecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder.Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice.Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.Characterisation of CDKL5 Transcript Isoforms in Human and MouseCDKL5 deficiency entails sleep apneas in mice.Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex.CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice.CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors.Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.Utilizing Animal Models of Infantile Spasms.Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.
P2860
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P2860
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
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name
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@ast
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@en
type
label
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@ast
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@en
prefLabel
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@ast
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@en
P2093
P2860
P50
P1433
P1476
Mapping pathological phenotypes in a mouse model of CDKL5 disorder
@en
P2093
Camilla Mattucci
Claudia Fuchs
Cornelius T Gross
Davide Silingardi
Elena Amendola
Eleonora Calcagno
Giuseppina Lonetti
P2860
P304
P356
10.1371/JOURNAL.PONE.0091613
P407
P50
P577
2014-05-16T00:00:00Z