Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study - Wikidata - awgldk - TriplyDB

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

http://www.wikidata.org/entity/Q33635992

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Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).Identification of Novel and Efficacious Chemical Compounds that Disturb Influenza A Virus Entry in vitro Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein-ligand binding affinity.Efficient soluble expression of active recombinant human cyclin A2 mediated by E. coli molecular chaperones.A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects.Glycerol based solvents: synthesis, properties and applications

P2860

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P2860

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

http://www.wikidata.org/entity/Q33635992

description

2012 nî lūn-bûn

@nan

2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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type

label

Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

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P1433

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P1433

ACS Medicinal Chemistry Letters

P1476

Solvent Selection for Insolubl ...... elopment: A TNF-α/SPD304 Study

@en

P2093

Anthi K Mettou

http://www.w3.org/2001/XMLSchema#string

George A Kontopidis

http://www.w3.org/2001/XMLSchema#string

Vagelis Rinotas

http://www.w3.org/2001/XMLSchema#string

P2860

The TNF and TNF receptor superfamilies: integrating mammalian biology

Signalling pathways of the TNF superfamily: a double-edged sword

Biological assay challenges from compound solubility: strategies for bioassay optimization.

Small-molecule inhibition of TNF-alpha.

High throughput solubility measurement in drug discovery and development.

Bridging solubility between drug discovery and development.

Fluorescence methods for studying equilibrium macromolecule-ligand interactions.

Structure based optimization of chromen-based TNF-α converting enzyme (TACE) inhibitors on S1' pocket and their quantitative structure-activity relationship (QSAR) study.

Proteins in organic solvents.

High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media.

P304

137-141

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P31

scholarly article

P356

10.1021/ML300380H

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P433

1

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P478

4

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P50

Christos Papaneophytou

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2012-11-29T00:00:00Z

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P5875

260248593

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P698

24900576

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P932

4027498

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