Small-molecule inhibition of TNF-alpha. - Wikidata - awgldk - TriplyDB

Small-molecule inhibition of TNF-alpha.

Small-molecule inhibition of TNF-alpha.

http://www.wikidata.org/entity/Q34562550

about

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease Structural conservation of druggable hot spots in protein-protein interfaces Dynamic dissociating homo-oligomers and the control of protein function Morpheeins – A New Pathway For Allosteric Drug Discovery~!2010-02-12~!2010-05-21~!2010-06-08~!Expanding the concepts in protein structure-function relationships and enzyme kinetics: Teaching using morpheeins Shape shifting leads to small-molecule allosteric drug discovery Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity Applicability of superfolder YFP bimolecular fluorescence complementation in vitro Phenothiazines inhibit S100A4 function by inducing protein oligomerization Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus Regulation of tumour necrosis factor signalling: live or let die Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?Structure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibility New binding mode to TNF-alpha revealed by ubiquitin-based artificial binding protein Advantages and application of label-free detection assays in drug screening.Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors.An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.In silico identification of an interferon inhibitor.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.Novel synthetic biscoumarins target tumor necrosis factor-α in hepatocellular carcinoma in vitro and in vivo.Small-molecule inhibitors of the interaction between TNF and TNFR.Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis Binding mode analysis of zerumbone to key signal proteins in the tumor necrosis factor pathway.Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays.

P2860

Q21093232-27048EB7-383E-4848-A1AA-FD1742D28523 Q24614979-F73E4D33-700A-438B-9D8C-AB262ECE3442 Q24619847-8A980171-196F-49A4-86A4-CFDB8A4B7DC1 Q24626890-CA621792-D638-4ECF-B5B0-7CEC43D4EC78 Q24646481-2C587D79-86EF-4638-8D2E-F6A5B416023E Q24656252-4D1C9BBF-1F7E-482A-AB64-D399587A88BE Q26775356-E12F7B96-7795-484F-96F3-A0A35292F6C2 Q26996645-63AADD40-53E1-475E-96BC-6EEC47FC5C70 Q27652896-4D81AA28-76F2-4CBC-933B-0478CDCFB971 Q27660911-6B29B71D-5416-40FC-A1BA-EFDCF60375B7 Q27661215-1E5917D1-204C-43FC-9E51-8AAE149E4699 Q27667288-046D4EFF-41C3-4A9D-9685-47E9E3C8C88E Q27674734-D98288A0-D9B1-4930-9446-68AEBB99528E Q27680467-A4D2CFAA-2FD2-409C-ADF6-A54AB1D84664 Q28262381-CE7DF247-98E1-471E-81B3-C3060C443572 Q28476115-1042CB2F-EC78-412C-B144-AC74F373BA9B Q28484296-2F04E7DD-1031-4A1D-99BF-816A61F57C55 Q28541379-18D43E9C-45C4-4C98-A38F-BE4FFB0D1291 Q28731927-234FB7D3-AA7E-4B59-8AE9-905DEE778AD7 Q30597676-D4EF527E-5C1A-4FA5-A5B6-6DBEBCCC4E38 Q30855659-DAB22239-645A-4857-A59B-7402B6D34F74 Q31096691-6DBCCA34-6B06-405D-B89C-BA2175240879 Q33556114-6AB9E6F4-807B-479C-AD39-643FCAFC01A0 Q33584492-183F4B25-FAEE-43B8-BECA-48EE68048813 Q33584683-B198EA35-0070-4D80-B7ED-4B9A39AACEA2 Q33635992-85E2C7ED-5CFE-4046-8FE3-D64B4D65D3DC Q33820227-F50A6E92-7BEC-4174-9362-CDDC590FCB65 Q33834499-8AE76BFE-1A37-4306-B4B7-D9A74D499824 Q33967157-353EC6CE-B981-489A-B5BE-CDC809A5C1C2 Q34135430-2B5474D7-7DF0-4BFD-96B2-D047DB90E81F Q34185471-B6570843-C1A8-4EE5-B662-3F8E59BACC42 Q34263719-BABCAB64-02F8-451E-97F7-1F5FBCCBE922 Q34509670-345B65AC-313B-43F1-A140-036511AD853E Q34519187-4B4F03A5-1BF8-496A-AB40-D9A02AED59AD Q34634233-EFF4B740-BDBF-42E1-86F0-A78A1FD3B04F Q34832185-9FE6F107-295E-4C43-B349-0BBC01936363 Q34954124-D1C075F3-AB30-4D0B-BE2E-8D2CEE7A50E4 Q34993747-D9B5A892-364E-466C-892C-D2337C2E667E Q35138933-60A26C25-4AE3-4CAF-A1C3-2621DCFB6DD8 Q35397776-D482BAE4-4626-4EEB-A090-0FEF08755A7A

P2860

Small-molecule inhibition of TNF-alpha.

http://www.wikidata.org/entity/Q34562550

description

2005 nî lūn-bûn

@nan

2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Small-molecule inhibition of TNF-alpha.

@ast

Small-molecule inhibition of TNF-alpha.

@en

Small-molecule inhibition of TNF-alpha.

@nl

type

label

Small-molecule inhibition of TNF-alpha.

@ast

Small-molecule inhibition of TNF-alpha.

@en

Small-molecule inhibition of TNF-alpha.

@nl

prefLabel

Small-molecule inhibition of TNF-alpha.

@ast

Small-molecule inhibition of TNF-alpha.

@en

Small-molecule inhibition of TNF-alpha.

@nl

P1433

Q34562550-EBCA29B3-C047-4E38-AF37-9420DAE7E23E

P1476

Q34562550-5AF37BEC-E838-487E-8C85-F138CFF7E292

P2093

Q34562550-06110EC4-9B19-4DF2-B798-6C22FC94306B

Q34562550-36DF32BF-F458-4BD0-9C31-A2D5B7F26C06

Q34562550-383A9974-5477-4095-86D2-D2E7E5DE8065

Q34562550-3C15D941-FAC1-43DD-ACA0-A5A4042C54B8

Q34562550-46842790-C4BE-4A78-854D-4C7B6FCBAF6E

Q34562550-4B771377-74B8-44BA-92F2-3E036547A139

Q34562550-4FE2DEE0-FC77-4119-8C13-1DB2313CE554

Q34562550-6118F1D6-A4C6-4251-AEB3-8A5087A34F26

Q34562550-63D97473-7E74-4D88-AFD0-7B06AF540FDB

Q34562550-67963CA6-F3EF-4EF4-9766-18F3FA93FE46

P304

Q34562550-98E31ED9-93F6-4AEF-8E66-B524FD8922D6

P31

Q34562550-204AA8D5-1F9C-4D64-BF40-EE840897AA8A

P356

Q34562550-121A4D76-FB57-463F-8CD4-DC6073739963

P407

Q34562550-11C6916D-7EC7-4625-86FD-130F415B4F24

P433

Q34562550-435F3DE6-67ED-4BFE-9048-501CAC2082CF

P478

Q34562550-37A78E88-CAC9-4B30-8420-D0A560789053

P577

Q34562550-84CAC6C4-801C-44D8-A113-93717B0C12F8

P5875

Q34562550-7BD616C8-D8EA-4421-A19D-6FCA028321C9

P698

Q34562550-22677DCC-3541-4524-83DE-F685884ED13A

P921

Q34562550-0212631D-2A0D-4D46-BE3C-9CE1570CCCE0

P356

SCIENCE.1116304

P1433

P1476

Small-molecule inhibition of TNF-alpha.

@en

P2093

Adrian Whitty

http://www.w3.org/2001/XMLSchema#string

Alexey A Lugovskoy

http://www.w3.org/2001/XMLSchema#string

Amy D Fung

http://www.w3.org/2001/XMLSchema#string

Andrew C Braisted

http://www.w3.org/2001/XMLSchema#string

Annemarie Stroustrup Smith

http://www.w3.org/2001/XMLSchema#string

Brian C Cunningham

http://www.w3.org/2001/XMLSchema#string

Eric S Day

http://www.w3.org/2001/XMLSchema#string

Graham Farrington

http://www.w3.org/2001/XMLSchema#string

Ingrid C Choong

http://www.w3.org/2001/XMLSchema#string

Jessica E Friedman

http://www.w3.org/2001/XMLSchema#string

P304

1022-1025

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCIENCE.1116304

http://www.w3.org/2001/XMLSchema#string

P407

P433

5750

http://www.w3.org/2001/XMLSchema#string

P478

310

http://www.w3.org/2001/XMLSchema#string

P577

2005-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7484628

http://www.w3.org/2001/XMLSchema#string

P698

16284179

http://www.w3.org/2001/XMLSchema#string

P921