A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation
about
Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latencyBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisOcular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycleChanges to euchromatin on LAT and ICP4 following reactivation are more prevalent in an efficiently reactivating strain of HSV-1.The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.Inducible cyclic AMP early repressor produces reactivation of latent herpes simplex virus type 1 in neurons in vitroHerpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of encephalitis in male BALB/c miceCellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsA mutation in the latency-related gene of bovine herpesvirus 1 disrupts the latency reactivation cycle in calves.Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosisInfection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency.A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Upregulation of mouse genes in HSV-1 latent TG after butyrate treatment implicates the multiple roles of the LAT-ICP0 locus.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Characterization of herpes simplex virus 2 primary microRNA Transcript regulationSodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse model.In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment.Weight loss and reduced body temperature determine humane endpoints in a mouse model of ocular herpesvirus infectionLatency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LATThe herpes simplex virus type 1 latency-associated transcript (LAT) enhancer/rcr is hyperacetylated during latency independently of LAT transcriptionHerpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro.Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype.A speculated ribozyme site in the herpes simplex virus type 1 latency-associated transcript gene is not essential for a wild-type reactivation phenotype.
P2860
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P2860
A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@ast
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@en
type
label
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@ast
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@en
prefLabel
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@ast
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@en
P2093
P2860
P1433
P1476
A herpes simplex virus type 1 ...... duced spontaneous reactivation
@en
P2093
A B Nesburn
B S Drolet
S L Wechsler
S M Slanina
P2860
P304
P577
1999-02-01T00:00:00Z