An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation.
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Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationLocal periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbitsReplication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.A mutation in the latency-related gene of bovine herpesvirus 1 leads to impaired ocular shedding in acutely infected calves.Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.A mutation in the latency-related gene of bovine herpesvirus 1 disrupts the latency reactivation cycle in calves.Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potentialComparison of adjuvant efficacy of herpes simplex virus type 1 recombinant viruses expressing TH1 and TH2 cytokine genes.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation.Activation of NF-κB in CD8+ dendritic cells Ex Vivo by the γ134.5 null mutant correlates with immunity against herpes simplex virus 1.The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation.The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation.A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies.Genome sequence of herpes simplex virus 1 strain McKrae.Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo.HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in miceRe-evaluating natural resistance to herpes simplex virus type 1.Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell lineHerpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses.Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival.Analysis of the genome of leporid herpesvirus 4.
P2860
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P2860
An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@ast
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@en
type
label
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@ast
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@en
prefLabel
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@ast
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation.
@en
P2093
P2860
P1433
P1476
An avirulent ICP34.5 deletion ...... vivo spontaneous reactivation
@en
P2093
A B Nesburn
N M Sawtell
R L Thompson
S L Wechsler
S M Slanina
W E Taylor
P2860
P304
P407
P577
1995-05-01T00:00:00Z