A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
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Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latencyHerpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic ConsiderationsPotential function of miRNAs in herpetic stromal keratitisBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisThe molecular basis of herpes simplex virus latencyRole of chromatin during herpesvirus infections.Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationTowards an understanding of the herpes simplex virus type 1 latency-reactivation cycleDevelopment and evaluation of SYBR Green-I based quantitative PCR assays for herpes simplex virus type 1 whole transcriptome analysis.Epigenetic regulation of latent HSV-1 gene expression.Changes to euchromatin on LAT and ICP4 following reactivation are more prevalent in an efficiently reactivating strain of HSV-1.The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal gangliaAlternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading framesThe PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growthLong-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latencySmall non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionThree herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue cultureThe 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic miceHerpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory gangliaSpontaneous molecular reactivation of herpes simplex virus type 1 latency in mice.Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional responseRecent progress in herpes simplex virus immunobiology and vaccine researchExpression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates.A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsHistone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cellsNeither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusDeacetylation of the herpes simplex virus type 1 latency-associated transcript (LAT) enhancer and a decrease in LAT abundance precede an increase in ICP0 transcriptional permissiveness at early times postexplant.HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons.LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.
P2860
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P2860
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A viral function represses acc ...... ted with herpes simplex virus.
@ast
A viral function represses acc ...... ted with herpes simplex virus.
@en
type
label
A viral function represses acc ...... ted with herpes simplex virus.
@ast
A viral function represses acc ...... ted with herpes simplex virus.
@en
prefLabel
A viral function represses acc ...... ted with herpes simplex virus.
@ast
A viral function represses acc ...... ted with herpes simplex virus.
@en
P2093
P2860
P1433
P1476
A viral function represses acc ...... ted with herpes simplex virus.
@en
P2093
P2860
P304
P407
P577
1997-08-01T00:00:00Z