Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. - Wikidata - awgldk - TriplyDB

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

http://www.wikidata.org/entity/Q33642230

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Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity Membrane lipids: where they are and how they behave Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1 Mechanisms for insulin resistance: common threads and missing links Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.Molecular mechanisms involved in hepatic steatosis and insulin resistance.Viewpoints on the way to a consensus session: where does insulin resistance start? The liver.Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.Early hepatic insulin resistance in mice: a metabolomics analysis.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ.High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins Glycerophosphate/Acylglycerophosphate acyltransferases.Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling Hepatitis C virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet.Rhein Elicits In Vitro Cytotoxicity in Primary Human Liver HL-7702 Cells by Inducing Apoptosis through Mitochondria-Mediated Pathway.The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion.Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding.Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.Effect of BI-1 on insulin resistance through regulation of CYP2E1.Hepatic triacylglycerol accumulation and insulin resistance.Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.

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P2860

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

http://www.wikidata.org/entity/Q33642230

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Hepatic overexpression of glyc ...... ats causes insulin resistance.

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Christopher B Newgard

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Cynthia A Nagle

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Gary W Cline

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Jie An

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Masakazu Shiota

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Reetta L Catlin

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Rosalind A Coleman

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Shuli Wang

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Tracy P Torres

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Zhen-Xiang Liu

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P2860

Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs

Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition

Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes

Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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10.1074/JBC.M611550200

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20

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282

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Gerald I. Shulman

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