Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. - Wikidata - awgldk - TriplyDB

Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.

Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.

http://www.wikidata.org/entity/Q33647720

about

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression Gonadotropin-releasing hormone agonists sensitize, and resensitize, prostate cancer cells to docetaxel in a p53-dependent manner Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies.(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells.A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection.Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.Natural product-based therapeutics for the treatment of cancer stem cells: a patent review (2010 - 2013).Recent advances in gossypol derivatives and analogs: a chemistry and biology view.The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.Gossypol induces apoptosis in ovarian cancer cells through oxidative stress.Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells.Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling.BH3 Mimetics for the Treatment of Prostate Cancer.Gossypol Inhibits Electron Transport and Stimulates ROS Generation in Yarrowia lipolytica Mitochondria.Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks.Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the and Growth of Malignant Mesothelioma

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Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.

http://www.wikidata.org/entity/Q33647720

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Molecular Cancer Therapeutics

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Gossypol induces apoptosis by ...... ostate tumor-initiating cells.

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P2093

Brian T Kawasaki

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Elaine M Hurt

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Jeffrey White

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John A Milner

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Suresh R Volate

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Young S Kim

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P2860

Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells

Enhanced phosphorylation of p53 by ATM in response to DNA damage

The biochemistry of apoptosis

Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control

Regulation of p53 stability and activity in response to genotoxic stress.

Androgen deprivation therapy for prostate cancer: new concepts and concerns.

Anticancer drug discovery and development throughout the world.

Androgen deprivation therapy for the treatment of prostate cancer: consider both benefits and risks

Investigations on gossypol: past and present developments.

CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

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2

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20124455

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2820604

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