High-resolution mapping of protein sequence-function relationships. - Wikidata - awgldk - TriplyDB

High-resolution mapping of protein sequence-function relationships.

High-resolution mapping of protein sequence-function relationships.

http://www.wikidata.org/entity/Q33658465

about

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis MUSI: an integrated system for identifying multiple specificity from very large peptide or nucleic acid data sets Causes of evolutionary rate variation among protein sites Protein stability: computation, sequence statistics, and new experimental methods Rational Protein Engineering Guided by Deep Mutational Scanning Massively parallel sequencing: the new frontier of hematologic genomics Neurogenomics of speech and language disorders: the road ahead Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domains Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations Computational Design of a Protein-Based Enzyme Inhibitor Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing Computational design of ligand-binding proteins with high affinity and selectivity The multiple-specificity landscape of modular peptide recognition domains High-throughput analysis of peptide-binding modules A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity Rheostats and toggle switches for modulating protein function Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions Selection on Network Dynamics Drives Differential Rates of Protein Domain Evolution Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions Predicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone design Determination of binding affinity upon mutation for type I dockerin-cohesin complexes from Clostridium thermocellum and Clostridium cellulolyticum using deep sequencing Viewing protein fitness landscapes through a next-gen lens.High-throughput profiling of point mutations across the HIV-1 genome.Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing.Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening.Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast Software for the analysis and visualization of deep mutational scanning data.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis Data Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.A comprehensive, high-resolution map of a gene's fitness landscape TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.Inferring fitness landscapes by regression produces biased estimates of epistasis.Identification of calpain substrates by ORF phage display Rosetta FlexPepDock ab-initio: simultaneous folding, docking and refinement of peptides onto their receptors.An experimentally determined evolutionary model dramatically improves phylogenetic fit.The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.

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P2860

High-resolution mapping of protein sequence-function relationships.

http://www.wikidata.org/entity/Q33658465

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

High-resolution mapping of protein sequence-function relationships.

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High-resolution mapping of protein sequence-function relationships.

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type

label

High-resolution mapping of protein sequence-function relationships.

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High-resolution mapping of protein sequence-function relationships.

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prefLabel

High-resolution mapping of protein sequence-function relationships.

@ast

High-resolution mapping of protein sequence-function relationships.

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High-resolution mapping of protein sequence-function relationships.

@en

P2093

Douglas M Fowler

http://www.w3.org/2001/XMLSchema#string

Elizabeth H Kellogg

http://www.w3.org/2001/XMLSchema#string

Jason J Stephany

http://www.w3.org/2001/XMLSchema#string

Stanley Fields

http://www.w3.org/2001/XMLSchema#string

P2860

A large genome center's improvements to the Illumina sequencing system.

Rapid mapping of protein functional epitopes by combinatorial alanine scanning

Statistical significance for genomewide studies

Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope

WW and SH3 domains, two different scaffolds to recognize proline-rich ligands

Protein tolerance to random amino acid change

Mapping the transition state and pathway of protein folding by protein engineering

A simple physical model for binding energy hot spots in protein-protein complexes

Macromolecular modeling with rosetta

Darwinian evolution can follow only very few mutational paths to fitter proteins

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741-746

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scholarly article

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10.1038/NMETH.1492

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9

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7

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Sarel J Fleishman

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2010-08-15T00:00:00Z

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45651101

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1043860674

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20711194

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2938879

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