Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
about
Chemical probes of endocannabinoid metabolismMonoacylglycerol lipase - a target for drug development?Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future AntidepressantsThe discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.Highly predictive ligand-based pharmacophore and homology models of ABHD6.Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitorsProteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.Chemical modulation of glycerolipid signaling and metabolic pathways.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Radiosynthesis and ex vivo evaluation of [(11)C-carbonyl]carbamate- and urea-based monoacylglycerol lipase inhibitors.Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas.Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine.
P2860
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P2860
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@ast
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@en
type
label
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@ast
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@en
prefLabel
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@ast
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@en
P2093
P2860
P356
P1476
Characterization of tunable pi ...... of endocannabinoid hydrolases.
@en
P2093
Alexander Adibekian
Jonathan Z Long
P2860
P304
P356
10.1021/JM9016976
P407
P577
2010-02-01T00:00:00Z