Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. - Wikidata - awgldk - TriplyDB

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.

http://www.wikidata.org/entity/Q33688527

about

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3K/Akt2 Signaling Pathway in Skeletal Muscle of KKAy Mice.The hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistance A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysidea herbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment.Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response.Zinc transporters, mechanisms of action and therapeutic utility: implications for type 2 diabetes mellitus.Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance.Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver.Crosstalk between insulin and Toll-like receptor signaling pathways in the central nervous system.Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice.Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.Protein Tyrosine Phosphatase 1B Inhibitors from the Stems of Akebia quinata.Selective Inhibition of PTP1B by Vitalboside A from Syzygium cumini Enhances Insulin Sensitivity and Attenuates Lipid Accumulation Via Partial Agonism to PPARγ: In Vitro and In Silico Investigation.Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1.Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials.Past and current perspective on new therapeutic targets for Type-II diabetes.Coumarins as potential antidiabetic agents.Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action.Pharmacometrics of 3-methoxypterostilbene: a component of traditional chinese medicinal plants.MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis Role of sodium tungstate as a potential antiplatelet agent.Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity.

P2860

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P2860

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.

http://www.wikidata.org/entity/Q33688527

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Inhibition of PTP1B restores I ...... naling in IRS2-deficient mice.

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Inhibition of PTP1B restores I ...... naling in IRS2-deficient mice.

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Inhibition of PTP1B restores I ...... naling in IRS2-deficient mice.

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Agueda González-Rodríguez

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Angela M Valverde

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Deborah J Burks

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Jose A Mas Gutierrez

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Manuel Ros

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Silvia Sanz-González

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P2860

Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation

Disruption of IRS-2 causes type 2 diabetes in mice

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

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10.2337/DB09-0796

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59

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40759444

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20028942

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2828646

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