DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. - Wikidata - awgldk - TriplyDB

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

http://www.wikidata.org/entity/Q33700188

about

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma DNA secondary structure at chromosomal fragile sites in human disease.DNA instability at chromosomal fragile sites in cancer Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy.Escherichia coli Rep DNA helicase and error-prone DNA polymerase IV interact physically and functionally DNA topoisomerases participate in fragility of the oncogene RET.The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?The role of fragile sites in sporadic papillary thyroid carcinoma Human RecQ helicases in DNA repair, recombination, and replication.Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.Role of DNA secondary structures in fragile site breakage along human chromosome 10 DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease.Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.Replication fork recovery and regulation of common fragile sites stability.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.FANCD2 Facilitates Replication through Common Fragile Sites.Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.Genome instability at common fragile sites: searching for the cause of their instability

P2860

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P2860

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

http://www.wikidata.org/entity/Q33700188

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

DNA structure and the Werner p ...... he common fragile site FRA16D.

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DNA structure and the Werner p ...... he common fragile site FRA16D.

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type

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DNA structure and the Werner p ...... he common fragile site FRA16D.

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DNA structure and the Werner p ...... he common fragile site FRA16D.

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DNA structure and the Werner p ...... he common fragile site FRA16D.

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DNA structure and the Werner p ...... he common fragile site FRA16D.

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Nucleic Acids Research

P1476

DNA structure and the Werner p ...... he common fragile site FRA16D.

@en

P2093

Kristin A Eckert

http://www.w3.org/2001/XMLSchema#string

Marietta Y W T Lee

http://www.w3.org/2001/XMLSchema#string

Patricia L Opresko

http://www.w3.org/2001/XMLSchema#string

Sandeep N Shah

http://www.w3.org/2001/XMLSchema#string

Xiao Meng

http://www.w3.org/2001/XMLSchema#string

P2860

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

Werner syndrome protein interacts functionally with translesion DNA polymerases

Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme

Replication slippage involves DNA polymerase pausing and dissociation.

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta

Molecular basis for expression of common and rare fragile sites

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1149-1162

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10.1093/NAR/GKP1131

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4

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38

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40456430

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19969545

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2831333

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