PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function - Wikidata - awgldk - TriplyDB

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

http://www.wikidata.org/entity/Q33701751

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How PI3K-derived lipids control cell division Phosphoinositide 3-kinase: friend and foe in cardiovascular disease PTEN regulates cilia through Dishevelled.Smoothened Regulation: A Tale of Two Signals.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.Polyphosphoinositide binding domains: Key to inositol lipid biology.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity Prion protein localizes at the ciliary base during neural and cardiovascular development, and its depletion affects α-tubulin post-translational modifications GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.INPP5E regulates phosphoinositide-dependent cilia transition zone function.Gene delivery to Nile tilapia cells for transgenesis and the role of PI3K-c2α in angiogenesis New insight into the intracellular roles of class II phosphoinositide 3-kinases.PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas.Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion.Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics.Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow.Mechanisms for nonmitotic activation of Aurora-A at cilia.PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts.Primary Cilia in Cystic Kidney Disease.The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane.Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.RAB21 Activity Assay Using GST-fused APPL1.Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.Rab GTPases in cilium formation and function.Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis.

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P2860

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

http://www.wikidata.org/entity/Q33701751

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

PI3K class II α controls spati ...... romote primary cilium function

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PI3K class II α controls spati ...... romote primary cilium function

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type

label

PI3K class II α controls spati ...... romote primary cilium function

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PI3K class II α controls spati ...... romote primary cilium function

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prefLabel

PI3K class II α controls spati ...... romote primary cilium function

@ast

PI3K class II α controls spati ...... romote primary cilium function

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J.DEVCEL.2014.01.022

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Developmental Cell

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PI3K class II α controls spati ...... romote primary cilium function

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Alessandra Boletta

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Carlotta Costa

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Daniel Monteyne

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Giorgio R Merlo

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Giulia Germena

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Jean Piero Margaria

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Stefano Marengo

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Tania Maffucci

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York Posor

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P2860

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

Human VPS34 and p150 are Rab7 interacting partners

Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes

Functional genomic screen for modulators of ciliogenesis and cilium length

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Functional dissection of Rab GTPases involved in primary cilium formation

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Pathways and mechanisms of endocytic recycling

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647-658

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10.1016/J.DEVCEL.2014.01.022

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6

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28

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David Pérez-Morga

Carlo Cosimo Campa

Federico GULLUNI

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261370024

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24697898

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4042153

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