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Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

http://www.wikidata.org/entity/Q33703468

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Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action The zinc-dependent protease activity of the botulinum neurotoxins SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.Review of the inhibition of biological activities of food-related selected toxins by natural compounds.Targeting botulinum A cellular toxicity: a prodrug approach.Current strategies for designing antidotes against botulinum neurotoxins.Challenges in searching for therapeutics against Botulinum Neurotoxins.Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.Tyrosine phosphorylation of botulinum neurotoxin protease domains Benzoquinones as inhibitors of botulinum neurotoxin serotype A.Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid.Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

P2860

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P2860

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

http://www.wikidata.org/entity/Q33703468

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

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Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

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type

label

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

@ast

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

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prefLabel

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

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Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

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P1433

Journal of the American Chemical Society

P1476

Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors

@en

P2093

Joseph T Barbieri

http://www.w3.org/2001/XMLSchema#string

Katerina Capková

http://www.w3.org/2001/XMLSchema#string

Kim D Janda

http://www.w3.org/2001/XMLSchema#string

Mark S Hixon

http://www.w3.org/2001/XMLSchema#string

Nicholas T Salzameda

http://www.w3.org/2001/XMLSchema#string

Peter Silhár

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P2860

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Inhibition of protein-protein association by small molecules: approaches and progress.

Identification of the major steps in botulinum toxin action.

The evolving field of biodefence: therapeutic developments and diagnostics.

Exosites in the substrate specificity of blood coagulation reactions.

The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison.

Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry.

L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.

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2868-2869

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10.1021/JA910761Y

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9

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132

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2010-03-01T00:00:00Z

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41450174

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20158239

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2832098

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