Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication

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A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin.

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Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

@zh-my

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Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

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Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@en

type

Item

label

Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@ast

Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@en

prefLabel

Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@ast

Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@en

P1476

Substrate-based inhibitors exh ...... inum Neurotoxin A intoxication

@en

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Bin Ji

http://www.w3.org/2001/XMLSchema#string

Edward Waichi Chan

http://www.w3.org/2001/XMLSchema#string

Jinglin Wang

http://www.w3.org/2001/XMLSchema#string

Jiubiao Guo

http://www.w3.org/2001/XMLSchema#string

Shan Gao

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Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype A

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling

Mechanism of action of tetanus and botulinum neurotoxins

Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond

Small molecules showing significant protection of mice against botulinum neurotoxin serotype A

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

[Botulinum toxin and wrinkles: few side effects and effective combining procedures with other treatments].

Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A

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srep16981

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16981

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scholarly article

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10.1038/SREP16981

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English

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Sheng Chen

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2015-11-20T00:00:00Z

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284279168

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26584873

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intoxication

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4653808

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Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication

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P2860

P2860

Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication

description

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type

label

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P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P478

P50

P577

P5875

P698

P921

P932