Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
about
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoidsRetinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).Retinoic acid synthesis and signaling during early organogenesisBiochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on tEnzymatic Metabolism of Vitamin A in Developing Vertebrate EmbryosExcessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ developmentGenetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acidOpposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradationTargeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retinaMerging protein, gene and genomic data: the evolution of the MDR-ADH family.RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis.Metabolism and transactivation activity of 13,14-dihydroretinoic acid.Cell signaling pathways in vertebrate lens regeneration.Transgenic mouse models for alcohol metabolism, toxicity, and cancer.Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis.Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout modelsVitamin A in reproduction and developmentRole of retinoid signaling in the regulation of spermatogenesis.Computational studies of human class V alcohol dehydrogenase - the odd sibling.Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism.Keeping an eye on retinoic acid signaling during eye development.Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism.Retinoic acid in the immune systemRetinoic acid signaling in mammalian eye development.New insights and changing paradigms in the regulation of vitamin A metabolism in development.Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase.Effects of low dose of ethanol on the senescence score, brain function and gene expression in senescence-accelerated mice 8 (SAMP8).Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate.Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina.LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1.Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1).Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Competition between ethanol clearance and retinoic acid biosynthesis in the induction of Fetal Alcohol Syndrome.
P2860
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P2860
Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Distinct retinoid metabolic fu ...... led in double null mutant mice
@ast
Distinct retinoid metabolic fu ...... led in double null mutant mice
@en
type
label
Distinct retinoid metabolic fu ...... led in double null mutant mice
@ast
Distinct retinoid metabolic fu ...... led in double null mutant mice
@en
prefLabel
Distinct retinoid metabolic fu ...... led in double null mutant mice
@ast
Distinct retinoid metabolic fu ...... led in double null mutant mice
@en
P2093
P2860
P356
P1476
Distinct retinoid metabolic fu ...... led in double null mutant mice
@en
P2093
Andrei Molotkov
Arnold E Cuenca
Louise Deltour
Mario H Foglio
P2860
P304
13804-13811
P356
10.1074/JBC.M112039200
P407
P577
2002-02-08T00:00:00Z