Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? - Wikidata - awgldk - TriplyDB

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

http://www.wikidata.org/entity/Q33714926

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Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug Discovery Concurrent Inflammation Augments Antimalarial Drugs-Induced Liver Injury in Rats The impact of duration of treatment on reported time-to-onset in spontaneous reporting systems for pharmacovigilance Assessing liver injury associated with antimycotics: Concise literature review and clues from data mining of the FAERS database.Drug-induced liver injury in older adults.In vitro platforms for evaluating liver toxicity.Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.Factors affecting drug-induced liver injury: antithyroid drugs as instances.Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.Age-related changes in the hepatic pharmacology and toxicology of paracetamol.Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.Acetaminophen-induced acute liver injury in HCV transgenic mice.Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure.Epstein-Barr virus-associated cholestatic hepatitis.Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment.Animal models of idiosyncratic drug-induced liver injury--current status.Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action.Toward predictive models for drug-induced liver injury in humans: are we there yet?Application of urine proteomics for biomarker discovery in drug-induced liver injury.Practical approaches to resolving reactive metabolite liabilities in early discovery.An overview on the proposed mechanisms of antithyroid drugs-induced liver injury.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Current limitations and future opportunities for prediction of DILI from in vitro.The pathogenesis of drug-induced liver injury.Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems.Current challenges and controversies in drug-induced liver injury.In silico Prediction of Drug Induced Liver Toxicity Using Substructure Pattern Recognition Method.Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results.Diphenhydramine as a Cause of Drug-Induced Liver Injury.Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study.MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.Traditional Chinese Medicine and Herb-induced Liver Injury: Comparison with Drug-induced Liver Injury.

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P2860

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

http://www.wikidata.org/entity/Q33714926

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

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Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

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Journal of Pharmacology and Experimental Therapeutics

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Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

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Patricia E Ganey

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Robert A Roth

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P2860

Hepatocellular damage from non-steroidal anti-inflammatory drugs

Adverse reactions to fluoroquinolones. an overview on mechanistic aspects

Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data.

Severe hepatotoxicity after therapeutic doses of acetaminophen.

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects.

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics

Effect of alcohol consumption on the gut.

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity.

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.

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