In vivo reduction of amyloid-beta by a mutant copper transporter - Wikidata - awgldk - TriplyDB

In vivo reduction of amyloid-beta by a mutant copper transporter

In vivo reduction of amyloid-beta by a mutant copper transporter

http://www.wikidata.org/entity/Q33715870

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Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance Metals and amyloid-beta in Alzheimer's disease Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution Disturbed copper bioavailability in Alzheimer's disease Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.The concentration of soluble extracellular amyloid-β protein in acute brain slices from CRND8 mice.Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Mitochondrial oxidative stress causes hyperphosphorylation of tau.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice Oral zinc reduces amyloid burden in Tg2576 mice Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.Copper binding to the Alzheimer's disease amyloid precursor protein A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease.Metal chaperones: a holistic approach to the treatment of Alzheimer's disease Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels Effects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice.Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.Amyloid-β as a modulator of synaptic plasticity Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells.Systems biology approach to Wilson's disease Copper modulation as a therapy for Alzheimer's disease?Iron regulatory protein 2 is involved in brain copper homeostasis.Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.Metal homeostasis in Alzheimer's disease.Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities.Links between copper and cholesterol in Alzheimer's disease.Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis.Therapeutics for Alzheimer's disease based on the metal hypothesis Pharmacotherapeutic targets in Alzheimer's disease Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.

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P2860

In vivo reduction of amyloid-beta by a mutant copper transporter

http://www.wikidata.org/entity/Q33715870

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2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

In vivo reduction of amyloid-beta by a mutant copper transporter

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In vivo reduction of amyloid-beta by a mutant copper transporter

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In vivo reduction of amyloid-beta by a mutant copper transporter

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In vivo reduction of amyloid-beta by a mutant copper transporter

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In vivo reduction of amyloid-beta by a mutant copper transporter

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In vivo reduction of amyloid-beta by a mutant copper transporter

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PNAS.2332851100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

In vivo reduction of amyloid-beta by a mutant copper transporter

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P2093

Amie L Phinney

http://www.w3.org/2001/XMLSchema#string

Bettina Drisaldi

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David Westaway

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Diane W Cox

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George A Carlson

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Janaky Coomaraswamy

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Jing Yang

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Joannis Sekoulidis

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M Azhar Chishti

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Patrick Horne

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P2860

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily

Elemental imbalances in the olfactory pathway in Alzheimer's disease

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

Toxic milk, a new mutation affecting cooper metabolism in the mouse

Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant

Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis

The pathology and trace element status of the toxic milk mutant mouse

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14193-14198

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scholarly article

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10.1073/PNAS.2332851100

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24

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100

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Peter Henry St George-Hyslop

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2003-11-14T00:00:00Z

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9008428

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14617772

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283568

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