Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. - Wikidata - awgldk - TriplyDB

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

http://www.wikidata.org/entity/Q33852318

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The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.Pathological and physiological functions of presenilins.Amyloid-β as a modulator of synaptic plasticity Neuronal death in Alzheimer's disease and therapeutic opportunities.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.gamma-Secretase: a multifaceted regulator of angiogenesis Presenilins: members of the gamma-secretase quartets, but part-time soloists too.Signature amyloid β profiles are produced by different γ-secretase complexes.The structure and function of Alzheimer's gamma secretase enzyme complex.The many substrates of presenilin/γ-secretase.Proteolytic cleavage of Notch: "HIT and RUN".Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease.Lessons from genome-wide association studies findings in Alzheimer's disease.Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease From soluble aβ to progressive aβ aggregation: could prion-like templated misfolding play a role?Biological function of Presenilin and its role in AD pathogenesis Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation.Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2 Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.Identification of gamma-secretase inhibitor potency determinants on presenilin.A pathogenic p.His169Asn mutation associated with early-onset Alzheimer's disease

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P2860

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

http://www.wikidata.org/entity/Q33852318

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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type

label

Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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prefLabel

Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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P1433

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PNAS.0500940102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Dissociated phenotypes in pres ...... lly distinct gamma-secretases.

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P2093

Bob Strome

http://www.w3.org/2001/XMLSchema#string

Chris Ebeling

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David Westaway

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George A Carlson

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Georges Levesque

http://www.w3.org/2001/XMLSchema#string

Heather Pelly

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Janaky Coomaraswamy

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Jing Yang

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M Azhar Chishti

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Matthew J Mazzella

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P2860

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

Skeletal and CNS defects in Presenilin-1-deficient mice

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Identification of distinct gamma-secretase complexes with different APH-1 variants

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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8972-8977

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10.1073/PNAS.0500940102

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25

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102

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Peter Henry St George-Hyslop

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2005-06-10T00:00:00Z

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7792123

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