Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.
about
TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavagesActivation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral ReplicationLipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathwayRegulation of Akt/PKB activation by tyrosine phosphorylationBiochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPLDomain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinaseInteraction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblastsTwo splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain.Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction.The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.Type 2 Diabetic Mellitus Is a Risk Factor for Nasopharyngeal Carcinoma: A 1:2 Matched Case-Control Study.Ca-dependent nonsecretory vesicle fusion in a secretory cellPanax Quinquefolius Saponin of Stem and Leaf Attenuates Intermittent High Glucose-Induced Oxidative Stress Injury in Cultured Human Umbilical Vein Endothelial Cells via PI3K/Akt/GSK-3 β Pathway.Hypoxia and leucine deprivation induce human insulin-like growth factor binding protein-1 hyperphosphorylation and increase its biological activityProtein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent.Molecular targets of breast cancer: AKTing in concertIGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cells.Phosphoinositide 3-kinase signaling in the vertebrate retina.Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms.Molecular imaging of tumor metabolism and apoptosis.Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway.Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase.Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia.Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus.Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.The expression of protein kinase B in gastric cancer cell apoptosis induced by 12-O-tetradecanoylphorbol-1, 3-acetate.Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats.Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway.Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction.Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats.Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells.Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and -dependent pathways.Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle.Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures.Molecular interaction maps as information organizers and simulation guides.Expression of apoptosis-regulatory genes in the hippocampus of rat neonates born to mothers with diabetes.
P2860
Q23910293-B9010150-5732-4556-93BA-F182AD901C9EQ27488801-82F158CC-98C1-4B57-A290-CFE82D4E780FQ28140459-0D423420-627F-4493-B738-DA69EC6A70E9Q28205568-279070BD-4C40-4D73-B82F-97F479DBC53FQ28540092-BCF68048-C391-4229-9B62-3FA07D62FA50Q28566841-AC0A086E-28FB-4237-AAF3-4700AD6C7DD6Q28609845-C32EEBAB-DEF1-47E1-97DA-7A7BD2A4D36FQ30164872-B6B86BA2-0276-4085-8D51-BEEA96EFA7BDQ30437463-2ABC5AEE-EF1E-41B0-94A5-928A3E4228DCQ31032454-640BFC48-D724-44FB-929D-F54F7ABBFB88Q33949444-2DEC169B-7364-4383-B356-831A9C138C1DQ35103906-F47500B4-AC2F-43D8-91DC-E2814E81D18EQ35983641-547D530C-AE27-4D6D-B8A4-0FD5023C77A2Q36167965-39727C13-F82E-4B9B-9A7C-3A4363D90C30Q36741180-ADC6FBC2-655B-457B-A4B4-4099C229429BQ37057776-D2BB4D28-F25F-42A5-90C2-16566084E636Q37072754-94D36084-0F9F-4B91-BA9B-1EC8E404DEDDQ37093066-C4CC0A49-C46A-4C02-BF0C-B3F1F379509FQ37183674-03828C4E-17E0-4ED5-ACFC-6567D95BE5E3Q37271044-0765B5A9-8697-404D-87C2-D81982C60EBEQ37463310-196557DB-FC7E-4F58-984B-9C1914FA5DB4Q37791182-22832DEB-5E5B-4DAA-8921-159E92B46D5AQ37876191-C30F9B97-DA6B-41F8-91A3-FFD03D01F893Q38696870-9A46A7D6-6328-47CF-B16F-05C8FE7FA713Q38711630-EAFDCB08-E191-4787-BB13-C3640BB8345AQ39260965-E6C0FEC3-F3AE-47AD-85C4-DEEA6D5A5E63Q39639135-C066272A-A6E0-41BD-8159-210B9672AC31Q39739265-C2A81CF4-8F19-4648-88D4-5BF522544132Q39880388-91305212-0686-4BD2-AC7E-C8C971362021Q41113178-27874F15-CF2A-4F7F-A303-3445DCB98CECQ42804551-BD4EE9E0-5FDA-4EF2-94D7-7C54DA48D657Q43693180-EDC9FF59-83EC-4F1A-A986-4B2B5983010EQ43706752-A3184DF2-32EC-4429-8F22-CAAC7D596DB2Q44211017-72B73E59-996D-44A8-8A25-0D22C5E90535Q44457883-8B44EDCB-ACAF-4EDB-A5F8-43FC45EFD16FQ44612954-3A27C16F-828C-46DE-B303-1D06C001FC68Q46414639-2A421720-5D46-44E5-B192-EBA78CB43471Q47687585-381AB9BC-2777-41AC-A572-FC3C7E02021BQ47870283-50DC4A1C-92C3-44A3-A168-47E8A40BC9A1Q47893218-15268871-D971-4CD2-82EC-B064003A3CAC
P2860
Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@ast
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@en
type
label
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@ast
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@en
prefLabel
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@ast
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@en
P2093
P1476
Mechanism of protein kinase B ...... cance for diabetes and cancer.
@en
P2093
Andjelkovic M
Brodbeck D
Hemmings BA
P304
P356
10.1016/S0163-7258(98)00071-0
P50
P577
1999-05-01T00:00:00Z