Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
about
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrestPhosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-AA cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis.EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases.Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 functionAurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsBiphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytesAurora-A kinase is required for centrosome maturation in Caenorhabditis elegansHuman TPX2 is required for targeting Aurora-A kinase to the spindleFunctional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinaseA dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cellsAurora Kinase Inhibitors: Current Status and OutlookThe Dawn of Aurora Kinase Research: From Fly Genetics to the ClinicNew molecular targets in mantle cell lymphomaFunctional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregationEssential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregationAurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochoresDrosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesisProbing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesisSkp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesisNDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitmentAurora-A interacts with AP-2α and down regulates its transcription activityMLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour targetAurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathwayA small C-terminal sequence of Aurora B is responsible for localization and functionArsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells.Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells.Aurora kinase inhibitors--rising stars in cancer therapeutics?Aurora A contributes to p150(glued) phosphorylation and function during mitosisA novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myelomaOverexpression of active Aurora-C kinase results in cell transformation and tumour formation.Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylationTanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and functionThe transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cyclePhase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.Sensing centromere tension: Aurora B and the regulation of kinetochore function.Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells.AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827.
P2860
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P2860
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@ast
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@en
type
label
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@ast
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@en
prefLabel
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@ast
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@en
P1476
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
@en
P2093
P304
P407
P478
112 ( Pt 21)
P577
1999-11-01T00:00:00Z