A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma - Wikidata - awgldk - TriplyDB

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

http://www.wikidata.org/entity/Q33944281

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Deficient spindle assembly checkpoint in multiple myeloma Drugging MYCN through an allosteric transition in Aurora kinase A Neuroblastoma A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells Maintaining Genome Stability in Defiance of Mitotic DNA Damage Emerging molecular classifications and therapeutic implications for gastric cancer Recent advances in the development of Aurora kinases inhibitors in hematological malignancies Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer Aurora kinase A in gastrointestinal cancers: time to target Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells Development of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells Aurora kinases as targets in drug-resistant neuroblastoma cells A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation.Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia.Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells.Aurora-A affects radiosenstivity in cervical squamous cell carcinoma and predicts poor prognosis.Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors TFF1 activates p53 through down-regulation of miR-504 in gastric cancer Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma.Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data.Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: phase 1 dose-escalation study.Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands.Update on aurora kinase inhibitors in gynecologic malignancies.Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.Targeting p53 by small molecules in hematological malignancies.Update on Aurora Kinase Targeted Therapeutics in Oncology.Issues in interpreting the in vivo activity of Aurora-A Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells.Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway.The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma.Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors

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P2860

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

http://www.wikidata.org/entity/Q33944281

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

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A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

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type

label

A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

@ast

A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

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prefLabel

A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

@ast

A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

@en

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A novel Aurora-A kinase inhibi ...... cle arrest in multiple myeloma

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Diana Cirstea

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Elisabetta Calabrese

http://www.w3.org/2001/XMLSchema#string

Giada Bianchi

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Güllü Görgün

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Hiroshi Ikeda

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Jeffrey Ecsedy

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Loredana Santo

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Madhavi Bandi

http://www.w3.org/2001/XMLSchema#string

Mala Mani

http://www.w3.org/2001/XMLSchema#string

Mei Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Mitotic kinases as regulators of cell division and its checkpoints

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

Aurora A, meiosis and mitosis

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein

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Kenneth C Anderson

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43099824

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