Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. - Wikidata - awgldk - TriplyDB

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

http://www.wikidata.org/entity/Q33755125

about

Mdm2 induces mono-ubiquitination of FOXO4 Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor Acetylation-dependent regulation of Skp2 function Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans Skp2: a novel potential therapeutic target for prostate cancer Clinical relevance of SKP2 alterations in metastatic melanoma Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells A new fork for clinical application: targeting forkhead transcription factors in cancer Cullin-RING ligases in regulation of autophagy The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Redox regulation of FoxO transcription factors Molecular functions of genes related to grain shape in rice Targeting the ubiquitin pathway for cancer treatment Autophagy in malignant transformation and cancer progression Cellular and molecular biology of aging endothelial cells Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.Bimodal regulation of FoxO3 by AKT and 14-3-3 FoxO transcription factors in oxidative stress response and ageing--a new fork on the way to longevity?FOXO transcription factors: their clinical significance and regulation.FOXOs, cancer and regulation of apoptosis Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer.EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity The FoxO family in cardiac function and dysfunction.FOXO1: a potential target for human diseases Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.

P2860

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P2860

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

http://www.wikidata.org/entity/Q33755125

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

@zh-tw

2005年论文

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name

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@ast

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@en

type

label

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@ast

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@en

prefLabel

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@ast

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@en

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PNAS.0406789102

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

@en

P2093

David I Smith

http://www.w3.org/2001/XMLSchema#string

Diping Wang

http://www.w3.org/2001/XMLSchema#string

Donald J Tindall

http://www.w3.org/2001/XMLSchema#string

Fang Wang

http://www.w3.org/2001/XMLSchema#string

Haojie Huang

http://www.w3.org/2001/XMLSchema#string

Jan M A van Deursen

http://www.w3.org/2001/XMLSchema#string

Kevin M Regan

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

Role of the F-box protein Skp2 in lymphomagenesis

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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102

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15668399

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545492

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