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Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signalingRegulation of p27 degradation and S-phase progression by Ro52 RING finger proteinPhosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerSCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigenSkp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescencePhosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKBDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerRole of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradationRole of the F-box protein Skp2 in adhesion-dependent cell cycle progressionThe role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processesThe F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesThe role of aberrant proteolysis in lymphomagenesisThree different binding sites of Cks1 are required for p27-ubiquitin ligationInduction of homologue of Slimb ubiquitin ligase receptor by mitogen signalingMutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cellsp27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisThe novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancersRole of F-box protein betaTrcp1 in mammary gland development and tumorigenesisThe gap junction-independent tumor-suppressing effect of connexin 43FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomasDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Expression of TYMS in lymph node metastasis from low-grade glioma.Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumoursThe ubiquitin system, disease, and drug discovery.Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway.Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53.Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.Regulation of Skp2 levels by the Pim-1 protein kinaseCks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignanciesIn vivo interference with Skp1 function leads to genetic instability and neoplastic transformationUbiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibilityUbiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.SKP2 high expression, KIT exon 11 deletions, and gastrointestinal bleeding as predictors of poor prognosis in primary gastrointestinal stromal tumors.Myc degradation: dancing with ubiquitin ligases.The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Role of the F-box protein Skp2 in lymphomagenesis
@ast
Role of the F-box protein Skp2 in lymphomagenesis
@en
Role of the F-box protein Skp2 in lymphomagenesis
@nl
type
label
Role of the F-box protein Skp2 in lymphomagenesis
@ast
Role of the F-box protein Skp2 in lymphomagenesis
@en
Role of the F-box protein Skp2 in lymphomagenesis
@nl
prefLabel
Role of the F-box protein Skp2 in lymphomagenesis
@ast
Role of the F-box protein Skp2 in lymphomagenesis
@en
Role of the F-box protein Skp2 in lymphomagenesis
@nl
P2093
P2860
P50
P3181
P356
P1476
Role of the F-box protein Skp2 in lymphomagenesis
@en
P2093
B A Schulman
G Inghirami
N P Pavletich
P2860
P304
P3181
P356
10.1073/PNAS.041475098
P407
P577
2001-02-20T00:00:00Z