Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
about
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cellsThe oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cellsThe Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.Extensions of MADM (mosaic analysis with double markers) in miceCrystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activationCBFbeta is critical for AML1-ETO and TEL-AML1 activity.Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organizationEfficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates.The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutationsMll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesisDichotomy of AML1-ETO functions: growth arrest versus block of differentiationAcute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.Modeling cancer in mice.When reverse genetics meets physiology: the use of site-specific recombinases in mice.An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasiaEpithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.RNA interference as a potential tool in the treatment of leukaemia.Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse lineAnimal models of acute myelogenous leukaemia - development, application and future perspectives.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Modeling thyroid cancer in the mouse.AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiencyGenetically engineered mouse models in cancer researchMouse chromosome engineering for modeling human disease.Review: genetic models of acute myeloid leukaemia.Applications of the site-specific recombinase Cre to the study of genomic imprintingStem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Mouse models for core binding factor leukemia.An overview of chronic myeloid leukemia and its animal models.Somatic Engineering of Oncogenic Chromosomal Rearrangements: A PerspectiveEfficient Genome Manipulation by Variants of Site-Specific Recombinases R and TD.Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation.Target-specific variants of Flp recombinase mediate genome engineering reactions in mammalian cells.Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model.Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach.
P2860
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P2860
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Inducible chromosomal transloc ...... ed recombination in the mouse.
@ast
Inducible chromosomal transloc ...... ed recombination in the mouse.
@en
type
label
Inducible chromosomal transloc ...... ed recombination in the mouse.
@ast
Inducible chromosomal transloc ...... ed recombination in the mouse.
@en
prefLabel
Inducible chromosomal transloc ...... ed recombination in the mouse.
@ast
Inducible chromosomal transloc ...... ed recombination in the mouse.
@en
P2093
P2860
P356
P1433
P1476
Inducible chromosomal transloc ...... ted recombination in the mouse
@en
P2093
P2860
P304
P356
10.1093/EMBO-REPORTS/KVD027
P577
2000-08-01T00:00:00Z